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Nails like birds claws. When this time was past, I Nabuchodonosor lifted up mine eyes unto heaven, and mine understanding was restored unto me again. Then I gave thanks to the highest. I magnified and praised him that liveth for evermore, whose power endureth always, and his kingdom from one generation to another: in comparison of whom all they that dwell upon the earth, are to be reputed as nothing. He handleth according to his will, among the powers of heaven and among the inhabitants of the earth: and there is none that may resist his hand, or say: what doest thou? At the same time was mine understanding given me again, and I was restored to the honor of my kingdom, to my dignity, an to my own shape again. My great estates and Princes sought unto me, and I was set in my kingdom again, so that I had yet greater worship. Then did I Nabuchodonosor, love, magnify and praise the King of heaven: for all his works are true, and his ways right. As for those that go on proudly, he is able to bring them down 1. Drug priming Drug cues . Stress . Summary . Methodological issues . Prior training for food reinforcement Noncontingent priming injections during training . Response rates during training Amount of drug exposure during training . The drug withdrawal period prior to tests for reinstatement . Side effects of the pharmacological and brain manipulations . Summary . Emerging issues . Does drug sensitization contribute to relapse to heroin and cocaine? . Drug priming and drug cues . Stress Application of the reinstatement model to mice . Concluding remarks and implications for addiction theories and treatment . Implications for addiction theories . Implications for treatment . Acknowledgments References.

Haemolytic disease. There were a number of other collaborations as well such as with the Blood Transfusion Service, the medical genetics laboratory under the direction of Victor McKusick ; at Johns Hopkins University in Maryland USA ; , researchers at the Ortho Pharmaceutical Corporation in New Jersey USA ; , and with personnel in an USA penitentiary that allowed novel ideas to be raised, explored, and tested page 32 ; . Many of the leading researchers could best be described as `amateurs' pages 35, 38 ; . They were physicians in Liverpool who cared for their patients during the day and then dealt with medical research projects usually in the evening after their clinical duties had concluded. At the beginning of their involvement in this research area, they had neither laboratory experience nor familiarity with many of the basic concepts. Nonetheless, they succeeded in putting forth and subjecting to experimental test the two-part `Liverpool hypothesis': that transfer of Rh-positive cells into Rh-negative mothers typically occurred at birth, not throughout pregnancy, and that the rapid removal of those fetal cells from maternal blood with anti-Rh anti-D ; antibody could prevent sensitization. The research surrounding treatment and prevention was accomplished with modest funding page 45 ; . In the present-day environment of big science and big budgets, it seems surprising how limited was the funding for this research. When substantial amounts of external support did come, in the form of a major Nuffield Foundation grant to the Liverpool group, it was only after the major part of the testing of the Liverpool hypothesis had already been accomplished. This Nuffield support allowed the establishment of a medical genetics research facility at the University of Liverpool which went on to grow in size and make key contributions in several different areas of medical genetics in the years that followed. Sadly, the departure of some of the original researchers left that unit vulnerable and, despite its illustrious history, it no longer exists. The clinicians and researchers were fortunate in the timely arrival of new technologies such as flexible catheters which greatly simplified the process of blood transfusions, the Kleihauer technique which was a crucial tool for measuring the presence of fetal cells in maternal blood, and the quantitative measure of anti-D antibody which permitted standardized anti-D delivery and rapidly pressed them into service pages 15, 1819, 3031.

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1. Similar safety profiles exist for biologic therapies: In section 3, page 41 of the HTA, it states "The combination involving infliximab, however, was associated with an increased risk of serious infection." It should be noted that the BSRBR data indicates that serious infections across all three biologics are similar in number. In a recent assessment of the BSRBR, data on incidence of serious infection were analysed on 2602, 2871 and 915 consecutive patients treated respectively with etanercept, infliximab, and adalimumab registered with the BSRBR for any rheumatic disease. The estimated incidence rate of all serious infections on biologic agents was 50 - 65 cases per 1, 000 patient-years, with no significant difference between the anti-TNF agents Dixon W et al, Rheumatology 2005 ; . Treatment Sequence of Infiximab vs. Other DMARDs: 1. Place of infliximab in relation to DMARD use in model is inconsistent with past NICE Guidance and BSR Guidelines: In the WMHTAC model, it appears that infliximab and the other anti-TNFs could have been used in variable places within a sequence of many DMARDs- infliximab could have been given after a sequence of 8 DMARDs, for example. Such a treatment approach is not consistent with both current British Society for Rheumatology BSR ; guidelines for prescribing anti-TNFs in RA Ledingham J et al, Rheumatology 2005 ; and previous NICE guidance on the use of etancercept and infliximab for the treatment of RA NICE, March 2002 ; . Both guidelines indicate that biologics specifically infliximab and etanercept for the NICE 2002 guidance ; can be prescribed in patients with clinically active RA that has not responded to at least 2 DMARDs, including methotrexate unless contraindicated ; . While "not responding to at least 2 DMARDs" could be an option generated in the WMHTAC model, the fact that the model randomly positions infliximab in various places within a sequence of potentially multiple DMARDs is not aligned with real world clinical practice. 2. Biases against anti-TNFs: As stated above, WMHTAC's analytic approach is to compare sequences of DMARDs with the insertion of an anti-TNF at various points in the sequence. The assessment team acknowledges the limitation of this approach by stating the "poor quality of the data on effectiveness of conventional DMARDs" page 215 ; , yet this forms the basis of comparison for the new and old drugs section 4.2.2 ; . We feel that this limitation is so serious as to be more than just a limitation- it likely invalidates the model. The approach severely biases the analysis against anti-TNFs in two ways. First, this assumes that the clinical trial populations in the literature for DMARDs are identical to those in the anti-TNF trials. On the contrary, examining the clinical characteristics of patients suggests that those enrolled in contemporary trials are among the top 25% of RA with the most severe disease based on nomograms of disease activity and severity [Wolfe F, J Med, 1997]. This is further confirmed by data suggesting faster HAQ progression in contemporary trials despite therapeutic improvements over the past 2 decades [Aletaha D, Ward M, Ann Rheum Dis in press]. Similarly, when looking at an early RA cohort, patients with more than 6-10 swollen joints have a higher probability of radiographic progression ranging from 82% to 93% depending on the presence or absence of RF positivity or erosive joint damage Drossaers-Bakker KW et al, Arth Rheum 2002 ; . Therefore, the analysis is biased by comparing anti-TNF treatment to DMARD treatment in a far less severe population.

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Investigational drugs the following drugs are currently being studied for use in treating patients with crohn disease: immunosuppressants tacrolimus prograf ; mycophenolate cellcept ; biologic drugs adalimumab humira ; cdp-571 humicade ; intercellular adhesion molecule-1 icam-1 ; interleukin 10 interleukin 11 mln-02 natalizumab antegren ; 1 2 3 « previous page glossary next page » next: for more information » printer-friendly format email to a friend last editorial review: 9 22 2005 emedicinehealth is a first aid and consumer health information site written by physicians for patients and consumers. B. Items asking for a particular course of action should not solicit the student's opinion What would you do? ; but rather, what the best action is What should you do? ; . Some clinical encounter items might require a specific action sequence. Consider the next example and adefovir. Adalimumab may be used alone or in combination with other dmards such as methotrexate
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March 1998 - Clinical Infectious Disease '98: A Management Review for the Practicing Physician, New York, NY. "Community-Acquired Pneumonia: Empiric vs. Specific Management." March 1998 - Grand Rounds, Overlook Hospital, Summit, NJ. "Community-Acquired Pneumonia." March 1998 - 26th Annual Joint Conference of New Jersey Thoracic Society and American College of Chest Physicians, New Brunswick, NJ. "Controversies in Community-Acquired Pneumonia." March 1998 - Department of Family Practice Grand Rounds CME Program, Huntington Hospital, Huntington, NY. "Treatment of Community-Acquired Pneumonia." March 1998 - 18th International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium. Chairman: Candida Infections Session. Participant, Pro-Con Debates: "Evidence Based Medicine Roundtable con ; ." "Invasive Diagnostic Techniques in VAP con ; ." Lectures: "Antibiotic Therapy of Pneumonia." "How I Select an Antibiotic." Participant, Round Table: Evidence Based Medicine. March 1998 - Department of Medicine's Grand Rounds, North General Hospital, New York, NY. "Community-Acquired Pneumonia." March 1998 - Charter Oak Conference-Connecticut Academy of Physician Assistants, Newport, RI. "Bacterial Resistance in Respiratory Infections." March 1998 - Grand Rounds, Peninsula Hospital, Far Rockaway, NY. "Community-Acquired Pneumonia." April 1998 - ACP Critical Care Medicine 1998 Course, San Diego, CA. "Dia0gnosis and Management of Severe Community Acquired and Severe Hospital Acquired Pneumonia." "Diagnosis and Management of Acute Respiratory Failure in Patients with COPD." April 1998 - CME Family Practice Series, Mid-Island Hospital, Bethpage, NY. "Pneumonia in the Critically Ill Patient." April 1998 - Lecture, St. Joseph's Hospital, Flushing, NY. "Management of Respiratory Tract Infection." April 1998 - Grand Rounds, Parker Jewish Institute, New Hyde Park, NY. "Pneumonia." April 1998 - Grand Rounds, Central Suffolk Hospital, Riverhead, NY. "New Strategies in Community-Acquired Pneumonia and adriamycin.

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9: 30 a.m. GIFT GUIDELINE IMPLEMENTATION FOR TOBACCO ; STUDY Joseph * , Arikian NJ, An LC, Nugent SM, Sloane RJ, and Pieper CF, GIFT Research Group 9: 45 a.m. IDENTIFYING BARRIERS TO ENTERING SMOKING CESSATION TREATMENT IN A COMMUNITY SAMPLE OF HEAVY SMOKERS Michael Businelle, Colleen E. Carney, M.A., and Amy L. Copeland, Ph.D. * , Louisiana State University 10: 00 a.m. FACTORS MEDIATING USE OF A SMOKING CESSATION TREATMENT SCT ; BENEFIT: EVIDENCE FROM WISCONSIN Timothy W. Bosworth, Ph. D. * , Marguerite E. Burns, M.A., and Michael C. Fiore, M.D., M.P.H. 10: 15 a.m. A PROSPECTIVE STATE OF THE ART SURVEY OF USE PATTERNS IN PATIENTS USING THE NICOTROL INHALER Edgar H. Adams * , Sc.D., Harris Interactive; John R. Hughes M.D., University of Vermont; Jill Guary, M.S., Harris Interactive; Mikael A. Franzon, Ph.D., Pharmacia Consumer Healthcare; Mary K. Maguire, Pharm.D., McNeil Consumer Healthcare; and Barbara H. Korberly, Pharm.D., Pharmacia Consumer Healthcare 9: 15 a.m. EFFICACY OF THE NICOTINE INHALER IN SMOKING REDUCTION Steve I Rennard * , M.D., 1 ; Elbert Glover, Ph.D., 2 ; Scott Leischow, Ph.D., 3 ; David M Daughton, M.S., 1 ; Penny Glover, M.Ed., 2 ; Myra Muramoto, M.D., 4 ; Tobias Danielsson, B ., 5 ; Bjrn Landfeldt, M.A., 5 ; ke Westin, M ., 5 ; Mikael Franzon, Ph.D., 5 ; and Urbain Swe M.D., Ph.D. 5 ; 1 ; University of Nebraska Medical Center, 2 ; West Virginia School of Medicine, 3 ; National Cancer Institute, 4 ; University of Arizona, and 5 ; Pharmacia Consumer Healthcare. 9: 30 a.m. COMPREHENSIVE ASSESSMENT OF TOBACCO RISK KNOWLEDGE Neil D.Weinstein, * Ph.D., Virginia Gibson, Ph.D., Erika A.Waters, B.A. and Dayna J. DeFeo, Rutgers University, and Paul Slovic, Ph.D. University of Oregon 9: 45 a.m. A RISK COMMUNICATION AID INCREASES RISK PERCEPTION AND QUITTING READINESS IN NONWHITE SMOKERS Susan Moran, M.D. * , Massachusetts General Hospital, Harvard Medical School; Peter Ubel, M.D., University of Michigan; Phyllis Gimotty, Ph.D., Katrina Armstrong, M.D., MSCE, University of Pennsylvania. 10: 00 a.m. EFFECTIVENESS AND COST BENEFIT OF THE AHRQ CLINICAL PRACTICE GUIDELINE FOR PREGNANT SMOKERS IN MEDICAID MATERNITY CARE Richard Windsor, Lesa Woodby, Myra Crawford, Thomas Miller, J. Michael Hardin, and Carlo DiClemente 10: 15 a.m. CHANGES IN SMOKING STATUS AFFECT THE LUNG FUNCTION OF WOMEN MORE THAN OF MEN: THE LUNG HEALTH STUDY John E. Connett, Ph.D. * , University of Minnesota, Minneapolis, MN and Robert P. Murray, Ph.D., University of Manitoba, Winnipeg, MB, Canada 10: 30 a.m. -11: 30 a.m Regency Ballroom Theme Lecture: In Harm's Way? Harm Reduction and the Future of Tobacco-Related Death and Disease Dr. Ken Warner, University of Michigan Introduction: Dr. Cheryl Healton 9: 00 a.m. NICOTINE REPLACEMENT TO REDUCE CIGARETTE CONSUMPTION IN SMOKERS WHO ARE UNWILLING TO QUIT: A RANDOMIZED TRIAL Etter JF, Laszlo E, Zellweger JP, Perrot C, and Perneger TV. 11: 30 a.m. -1: 30 p.m Harborside Center Poster Session 3 Lunch will be available for purchase in the lobby atrium from 11: 30 a.m.-12: 30 p.m. ; 11: 30 a.m.-1: 30 p.m Harborside Center Exhibit Hall Open.

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Mr. Donald L. McCollister, President of Harmony, L.L.C. was elected to Louisiana State University's Construction "Hall of Fame" for the year 2001. Mr. McCollister presently serves as a board member on the LSU Construction Industry Advisory Council and is also an active supporter of several other campus construction organizations, including the Construction Student Association and Christians in Construction Engineering & Design. Don has been employed by Turner Industries for over 38 years. Congratulations, Don and agenerase.
TABLE 60 Third TNF inhibitor following adalimumab and infliximab 20, 000 patients ; Option Etan Base Comparison Etan Base Comparison Etan Base Cost ; 56, 640 1, Diff. cost ; 41, 250 ICER per QALY ; 54, 900 QSE 256 50 QSE 248 QALYs 5.2256 4.4743 Diff. QALY 0.7513 Quasi-CI 50, 600 to 60, 100 QSE 0.0318 0.0279 QSE 0.0319.
NPHS, Household Component, Cycle 6 2004-2005 ; FV N2B FV A 2B INTERVIEWER: Select the reporting period. 1 2 3 Q3A FV A 3A Daily Weekly Monthly Yearly hard edit if FV Q2A more than 20; warning if more than 5 ; hard edit if FV Q2A more than 90; warning if more than 10 ; hard edit if FV Q2A more than 200; warning if more than 10 ; warning if FV Q2A more than 12 and aggrenox.

Agents Not Recommended for Approval by an FDA Advisory Panel or the FDA cont. ; Pleconaril Selegiline Tecastemizole Agents Scheduled for Review by an FDA Advisory Panel Agalsidase beta Agalsidase alfa Fabrazyme Genzyme ; Replagal Transkaryotic Therapies ; Gilead ; New Drug or Supplemental Applications Filed by Manufacturer Imatinib mesylate Gleevec Novartis ; MethyPatch Noven Pharmaceuticals ; Eloxatine Sanofi-Synthelabo ; Estrasorb Novavax ; First-line treatment of patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia CML ; Transdermal system for the treatment of attention-deficit hyperactivity disorder Second-line treatment in patients with advanced colorectal cancer Topical estrogen replacement therapy lotion using micellar nanoparticle technology ; for symptomatic menopausal women Treatment of alcohol dependence Forest Laboratories ; Adalimumab Abbott Laboratories ; Adefovir dipivoxil Gilead ; Anastrozole Arimidex AstraZeneca ; Treatment of moderate-to-severe rheumatoid arthritis, 4 02 with or without methotrexate, in patients who have had an inadequate response to one or more traditional diseasemodifying antirheumatic drugs DMARDs ; Treatment of patients with chronic hepatitis B, including treatment-nave and treatment-experienced patients Treatment of early breast cancer in postmenopausal women 3 02 3 continued ; 7 02 Treatment of Fabry disease Treatment of Fabry disease 9 02 9 Picovir ViroPharma ; Treatment of viral respiratory infection in adults 3 02 3.
In a meta-analysis of 11 high quality trials in a wide variety of surgical patients, graded compression elasticated stockings GCS ; reduced DVT by 68%, although their effect on PE and mortality were unclear.31 Unlike other prophylactic measures, they appear to be cost-saving, 32 and are routinely used in high-risk surgical patients. Although there have been no large trials evaluating GCS in stroke patients, their effectiveness in this subgroup is currently being investigated in a multi-centre trial. Based on surgical data, they have been recommended as standard care post-stroke in the interim.33 Intermittent pneumatic compression devices help prevent DVT in general, orthopaedic and neurosurgical patients with a magnitude of effect comparable to that of heparin, and are therefore a useful alternative in patients at high risk of bleeding. However, there is less data with regard to PE and they have not been shown to reduce total mortality.1, 34 They have also been shown to reduce both DVT and PE post-stroke, 35 although they are not ideally suited for the prolonged use often needed in these patients, and tend to be less well tolerated in this population than other prophylactic measures.36 and alefacept.

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A brief history of refrigerators and refrigerants Henrietta Harrison, Senior Toxicology Information Scientist CIRS Brief summary of history of refrigeration Before mechanical refrigeration systems were introduced, food was cooled with ice and snow. The first known artificial refrigeration was demonstrated by William Cullen, 1748, with the first practical refrigerating machine built in 1834 by Jacob Perkins. This used ether in a vapour compressing cycle. From the 1800s until 1929 gases such as ammonia NH3 ; , methyl chloride CH3Cl ; , and sulphur dioxide SO2 ; were utilised as refrigerants. Several fatal accidents occurred in the 1920s when methyl chloride leaked out of refrigerators. As a consequence Freons were developed and became standard for home systems. Almost 50 years passed between the introduction of CFCs and recognition of their harm to the environment when released. Specific concerns relate to their depletion of stratospheric ozone and to possible global warming by their actions as greenhouse gases. Ironically, the high stability of CFCs enables them to deliver ozone-depleting chlorine to the stratosphere. The same stability prolongs their atmospheric lifetimes, and thus their persistence as greenhouse gases. CIRS data on leaking ammonia refrigerators in health care facilities Industrial refrigerators in the UK may still use ammonia as their refrigerant and can pose a health risk. This is borne out by incidents reported to CIRS. Between January 2000 and December 2002 CIRS had 132 CI reported to them that involved health care facilities. Of these 11% 15 ; involved leaking fridges and aleve. Figure 4 a ; Cox proportional hazards regressions showing survival times of first-ranking dominant in terms of mating priority ; , secondranking, and third-ranking males. After 66 days, the surviving males eight dominant and two second ranking ; were released into the wild. b ; Cox proportional hazards regressions showing survival times of first-ranking, second-ranking, and third-ranking males in terms of body weight within each container. The most dominant males survived longest, but body weight alone did not influence survival time and adalimumab. Wayne P. Gulliver. Chairman and Medical Director, NewLab Clinical Research Inc. Chairman of Dermatology, Memorial University of Newfoundland, Chairman of Dermatology, St. John's Health Care Corporation, St. John's, NL & Labrador, Canada Since the mid-1960's, under the auspicious beginnings of Danish Dermatologist Gunnar Lomholt, thousands of genetic studies and analyses have not only established a definite genetic component of psoriasis - a chronic inflammatory dermatosis - but have both discovered and mapped several psoriasis susceptibility loci: PSORS1 on 6p21.3, PSORS2 on 17q, PSORS3 on 4q, PSORS4 on 1cen-q21, PSORS5 on 3q21, PSORS6 on 19p, and PSORS7 on 1p, consequently narrowing the search for the precise susceptibility allele which has managed, so far, to elude the conquests of modern science. As these genetic investigations have grown in both scope and technological sophistication, so too have they advanced on the therapeutic level. As current psoriasis research focuses on T-cell mediation and hyperproliferation, and the function of the skin as an immunological tissue, multiple breakthroughs in the treatment of psoriasis, involving tumor necrosis factor TNF-alpha ; inhibitors - primarily alefacept, infliximab, and etanercept - have begun to emerge for the effective treatment of psoriasis. As current psoriasis research focus on T-cell-mediation hyperproliferation and the function of the skin in its Immunological tissue, multiple breakthroughs in the treatment of psoriasis which target genes in psoriasis susceptibility loci are being used anti TNF's and PSORS1, infliximab, etanercept, onercept and adalimumab or in development such as anti-IL8 and rh IL10 in PSORS3; ICAM-1 topical inhibitor located in PSORS6 and anti CD2 located in PSORS7 ; . Further studies to identify new potential targets are on-going. We can expect new therapies to immerge to targets including HLACw6 which has been identified as a psoriasis susceptibility gene in PSORS1 found in the Newfoundland and Labrador population and confirmed in the Icelandic population and alfuzosin.

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To be able to utilize our future colleagues both as nursing assistants and unit coordinators throughout the summer. We are striving to improve our clinical practice. Nellee Fine, N Kathie Jose, RN, MSN, Chief Nursing Officer RN, MA, AOCN, has started her new position as oncology clinical nurse specialist and has begun working with the staff to s we celebrate Nurses Week 2002, we at Lahey are promote the cancer care program. With the guidance of the reminded of how fortunate we are to have such a high Policy Coordination and Development Council, we are in the caliber of nurses. "Nurses" do indeed "care for America, " process of redesigning the nursing documentation system with and here in Massachusetts the nurses at Lahey Clinic provide new flow sheets in ambulatory care, critical care, ED, and excellent care for each of our patients. med surg. Our initial nursing assessment documentation has This is an exciting year to be a nurse at Lahey. We have been revised to reflect the implementation of care based on the opened a new medical surgical area, the Nursing Resource assessment. Our orientation process has been improved with Center is open, and many of our goals for 2002 have already additional preceptor updates and continued re-evaluation. The been met. The loan forgiveness program continues to attract Nursing Research Series is ongoing, and we currently have two and reward participants. Currently, 49 staff nurses actively doing research within the Lahey have taken advantage of this program: 11 nurs community. es have received reimbursement for completing An important goal of 2002 is the establishassociate's degrees, 26 for bachelor's Celebrate the theme ment of a nursing quality and safety plan. The degrees, and two for master's degrees, with new restraint policies are on line, and an entireof National additional staff receiving loans for their current ly new self-study module regarding restraints is educational programs. Nurses Week: in use. We continue to study the area of patient One of the goals for this year is to establish falls and are introducing a new fall risk assessNurses Care a professional practice model. This is being ment and protocol. Both the Quality and Safety developed by the Professional and Education for America Council and the Clinical Practice Council are Council to provide opportunities for nurses to working on safer medication delivery and nosoexpand their areas of practice. The council is comial infection control. Deborah Ursino, clinical educator on 7 also compiling a Nursing West and head of the Pain Management Task Force, has been Resource Directory and instrumental in establishing pain assessment and treatment devising a professional prodocumentation. gression system for more forAnother important goal is improving communication among at .Lahey . mal development of career staff. We will continue distributing the weekly Nursing paths. We are creating a May June 2002 Community Calendar and publishing Notes on Nursing, and we clinical team leader position are looking to establish a Nurse-Physician Relationship ADVISORY BOARD for the off-shifts to further Nancy Rainier, RN, Chair Committee as well as increasing attendance at staff meetings enhance the clinical abilities Linda Campbell, RN Marie Catman, RN and staff assemblies. In today's world, change happens fast, of newer nurses. By increasKathleen Deleskey, RN June Williams, RN and we are committed to keeping you informed. ing the use of per diem pool EDITORIAL BOARD Nursing at Lahey Clinic is meeting the goals that we have nurses, we hope to encourMaura Flynn, LPN, Dermatology set for ourselves. There is much work to be done but I know Carmela Horlitz, RN, Research age staff nurse participation Nancy Lapointe, RN, OR that we have the enthusiasm and the skills to enhance our in the nursing councils. We Geraldine Lau, NP, Lahey Billerica Jane Lloyd, RN, Pediatrics practice and care for America, our patients, and each other. are also encouraging staff to Pamela McPhail, RN, OR Merrie Watters, RN, Pre-op Congratulations to all of you during Nurses Week 2002, and attend our frequent educaDESIGN MANAGING EDITOR thank you. tional programs by prorating.

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Peter C. Allen Two Poems CONVINCING MARIA TO MARRY ME I courting with my clothes on, crossing the street to enquire about you. Sometimes we sit in the living room or the kitchen. Today we go upstairs. We are crossed, side by side, falling like the maple seed. At the three-two bar on Saturday, the sky is the limit for the afternoon bachelor and the old fool, the sot who calls his wife a whore with his daughter sitting there. He was not born yesterday. Then cooking dinner and phone calls. Everything is tender, fragile. A baby cries. No one can soothe her though many hands flutter, the long fingers comforting. The semen of an ordinary man can repopulate this planet. When I look at you, I want children. I gather minerals, the peace pipe, a big black cat. I speak of the blood and the hearth. Surely, these remain. I would build a bed that could not be moved. I would take only what is offered and alimta.
4 pre-filled syringes, each containing 40 mg adalimumab 4 alcohol pads 5. METHOD AND ROUTE S ; OF ADMINISTRATION and adefovir. All indated blood components and derivatives for transfusion must be stored under the conditions specified in the following table so that purity, safety, and potency are optimal. Compliance with proper storage conditions must be verified on all Product Return Transfer forms. All environmental units used for storing blood components and certain derivatives must be equipped with alarms and or temperature monitoring devices. Federal regulations state the following requirements which apply to all blood establishments: "Equipment shall be observed, standardized, and calibrated. This includes but is not limited to temperature recorders, laboratory thermometers, electronic thermometers." In addition, temperature monitoring equipment requires performance checks in accordance with 21 CFR 606.60 a ; which states: "Equipment used in the collection, processing, compatibility testing, storage and distribution of blood and blood components shall be maintained in a clean and orderly manner and located so as to facilitate cleaning and maintenance. The equipment shall be observed, standardized and calibrated on a regularly scheduled basis as prescribed in the Standard Operating Procedures Manual and shall perform in the manner for which it was designed so as to assure compliance with the official requirements prescribed in this I TEM STO R AG E chapter for blood and blood products." TEM P.oC ; NOTE: The CODE OF FEDERAL REGULATIONS Parts 200 and 600 ; are for sale by: Superintendent of Documents Government Printing Office Washington, DC 20402 202 783-3238 and allergen.
We are g rateful to koji matsuo de par tment of internal medicine, suzuka general hospital, 1275-53 yamanohana, yasuduka-cho, suzuka city, mie prefecture, 513-8630, japan ; and mie torii department of cellular and molecular immunology, mie university graduate school of medicine, 2-174 edobashi, tsu city, mie prefecture, 514-8507, japan ; for expert assistance.

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