Capecitabine generic name
6 Tannock IF, de Wit R, Berry WR et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004; 351: 15021512. Scheithauer W, McKendrick J, Begbie S et al. Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial. Ann Oncol 2003; 14: 17351743. Wolmark N, Wieand HS, Kuebler JP et al. A phase III trial comparing FULV to FULV + oxaliplatin in stage II or III carcinoma of the colon: results of NSABP Protocol C-07. J Clin Oncol 2005; 23: 2465. Mamounas EP. NSABP breast cancer clinical trials: recent results and future directions. Clin Med Res 2003; 1: 309326. Montero A, Fossella F, Hortobagyi G et al. Docetaxel for treatment of solid tumours: a systematic review of clinical data. Lancet Oncol 2005; 6: 229239. Wang J, Halford S, Rigg A et al. Adjuvant mitozantrone chemotherapy in advanced prostate cancer. BJU Int 2000; 86: 675680. Rosenbaum E, Kibel A, Roth B et al. A pilot multicenter phase II trial of.
Folprecht et al. Drug insight: metastatic colorectal cancer--oral fluoropyrimidines and new perspectives in the adjuvant setting. Nat Clin Pract Oncol 2005; 2 11 ; : 578-87. Xeloda Capecitabine ; [package insert]. Nutley, NJ. Roche Pharmaceuticals, 2005.
Sotalol treatment resulted in the highest overall effirate 68.4% ; . Complete suppression was achieved in 22 of patients 57.9% ; , and partial response was achieved in another four patients 10.5% ; . In only three of 12 patients not responding to monotherapy with oral sotalol, ventricular tachycardia induction was suppressed completely by amiodarone n 1 ; or combination of sotalol with class I agents n 2 ; , whereas the remaining nine patients proved drug refractory after serial testing with 3.82.3 drugs, including amiodarone in five cases. Nonpharmacological therapy was performed in eight of these patients. The remaining patient was discharged on sotalol despite persistent ventricular tachycardia induction. Amiodarone proved to be effective according to the electrophysiological criteria in only two of 13 patients 15.4% ; . Ventricular tachycardia induction was unchanged in nine patients, six of whom had spontaneous ventricular tachycardia recurrences after 77 months range, 1-18 months ; during a total follow-up of 1719 months range, 1-51 months ; . The remaining two patients were followed clinically without programmed ventricular stimulation after the loading phase. Both had spontaneous ventricular tachycardia relapses after 3 and 12 months, respectively, and amiodarone treatment was discontinued. Class Ia and lb drugs as well as class Ic agents were effective in only 5.6% and 12.0%, respectively. Because several patients received more than one drug of the same group, the total number of drug tests exceeded the number of patients. Only one of 28 tests 3.6%; disopyramide ; performed with class Ia or lb drugs and three of 57 tests 5.3%; flecainide, propafenone, aprindine ; with class Ic agents were successful. ; 3-Blockers n 7 ; and verapamil n 5 ; failed in all patients treated. Drug combinations were effective in four of 26 patients 15.4% ; in whom the individual agents had previously failed. Combinations of class I drugs with sotalol n 10 ; or amiodarone n 4 ; were effective in two patients each, whereas combinations of two class I drugs n 5 ; or class I drugs with P-blockers n 7 ; showed no beneficial effect. Follow-up. Thirty-one of 42 patients 73.8% ; with inducible ventricular tachycardia were discharged on pharmacological treatment guided by serial drug testing, whereas the remaining 11 patients 26.2% ; were.
Capecitabine generic name
Yoo-hoo. Anyone home?" I hurried to the door to greet Emma, removing the dirty gloves from my hands and placing them on the countertop as I exited the kitchen. She was early. Today my husband, Mel, and I were celebrating our twenty-fifth wedding anniversary. Our children, Shannon, Liam, and Rebecca, and the few other guests we had invited would not begin arriving for another two hours or so. Mel had driven to the store to buy a few items that we had overlooked for the evening's festivities. I was spending a few minutes cleaning the kitchen before I would begin the next round of cooking. "Hullo, luv. I the first to arrive as usual?" Emma asked chuckling, as I opened the front door and hugged her. "Just making sure my favorite foods aren't gone before I have a chance to sample them, " she explained. "But you already know that all foods are my favorites!" she added, punctuating her notinaccurate self-appraisal with her trademark robust laugh. It was true that Emma enjoyed a hearty meal. And she usually tried to make sure that visitors to her home partook just as heartilyno one ever left her home hungry if she could help it. More often than not they were carrying a container of leftovers for good measure as they departed. "Here, " she said, handing me a package of what was no doubt something edible. "Mel's favorite." She didn't have to tell me what was in the package. She almost never came to visit us without bringing him one of her tasty shepherd's pies. But food was not Emma's real reason for arriving early, I knew. She just wanted to give me a hand with the preparations for the celebration. That, and to unburden some of her lingering grief over the death of her husband, Edward, before too many other guests had arrived. It was about one year since he had died. Although Emma made a good show of being her normally jolly self when others were around, with me she was more willing to let her guard down and share her true feelings, even allow a tear or two to make an appearance if she was in an especially blue mood at the time. Though I was young enough to be Emma's daughter, that had never been an obstacle to the friendship that had developed between us almost as soon as.
Dr love: the number of physicians who believe that capecitabine can be regarded as equivalent to 5-fu in the neoadjuvant, adjuvant and metastatic settings is pretty intriguing.
5. Zelek L, Barthier S, Riofrio M et al. Weekly vinorelbine is an effective palliative regimen after failure with anthracyclines and taxanes in metastatic breast cancer. Cancer 2001; 92: 22672272. Vogel C, O'Rourke M, Winer E et al. Vinorelbine as first-line chemotherapy for advanced breast cancer in women 60 years of age or older. Ann Oncol 1999; 10: 397402. Borquez D, Vanhoefer U, Oberhoff C et al. Phase I II study of vinorelbine in combination with a weekly schedule of folinic acid and infusional 5-FU in patients with metastatic breast cancer. Proc Soc Clin Oncol 2000; 19: 109 Abstr 420 ; . 8. Berruti A, Sperone P, Bottini A et al. Phase II study of protracted fluorouracil infusion as second- or third-line approach for advanced breast cancer patients previously treated with anthracyclines. J Clin Oncol 2000; 18: 33703377. Sawada N, Fujimoto-Ouchi F, Ishikawa T et al. Antitumor activity of combination therapy with capecitabine plus vinorelbine, and capecitabine plus gemcitabine in human tumor xenograft models. Proc Assoc Cancer Res 2002; 43: 1088 Abstr 5388 ; . 10. Lorusso V, Crucitta E, Silvestris N et al. A phase I study of capecitabine in combination with vinorelbine in advanced breast cancer. Clin Breast Cancer 2003; 4 2 ; : 138 141. 11. Stuart N, Bishop J, Johnson S et al. Vinorelbine and capecitabine for advanced breast cancer - a phase II study showing good activity and potential for further development. Proc Soc Clin Oncol 2003; 22: 46 Abstr 183 ; . 12. Ahn J, Kim S, Ahn S et al. Phase II study of capecitabine and vinorelbine in anthracycline and taxane pretreated breast cancer: Final results. Proc Soc Clin Oncol 2003; 22: 54 Abstr 216 ; . 13. Freyer G, Delozier T, Lichinster M et al. Phase II study of oral vinorelbine in first-line advanced breast cancer chemotherapy. J Clin Oncol 2003; 21: 3540. Gligorov J, Beerblock K, Selle F et al. Capecitabine and oral vinorelbine in metastatic breast cancer patients: Preliminary experience. Proc Soc Clin Oncol 2003; 22: 88 Abstr 351.
Capecitabine dissolutionFigure 4. Mean diurnal intraocular pressure IOP ; levels at 8 AM, 10 AM, and 4 at week 26 by treatment group and capsicum.
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Capecitabine toxicity polymorphisms
Eptomeningeal metastasis LM ; 2 develops in up to 5% patients with breast cancer. It causes neurological disability and death because of damage to the brain, cranial nerves, and spine. Standard therapy for LM consists of radiotherapy to symptomatic sites within the neuraxis and or intra-cerebrospinal fluid intra-CSF ; chemotherapy. The role of systemic chemotherapy for LM is not well defined. We report a patient with breast cancer and diffuse LM who demonstrated clinical, neuroimaging, and CSF response to capecitabine Xeloda, Roche Laboratories, Nutley, NJ ; monotherapy at 12 months and carbachol.
Capecitabine nasopharyngeal cancer
Due to an excess of drug-related fatalities in the raltitrexed arm The IDMC also recommended that a further safety and efficacy evaluation should be carried out The PETACC Steering Committee agreed to follow these recommendations and also felt that the observed excess mortality in the presence of a milder toxicity profile, in terms of gastrointestinal and bone marrow toxicity, was puzzling and needed further investigation. However, the sponsor, after having taken a review of in-house information, which was shared with the study chairman and statistician, decided to close the trial Because no formal interim efficacy analysis, as requested by the IDMC, was undertaken, the justification for this decision remains unsettled. As a result, the planned statistical methods section of the protocol has been amended. However, although the full number of patients was not recruited, a statistical analysis of disease-free survival in the first 1000 patients randomized on or prior to 15 January 1999 is now planned at 4.5 years minimum follow-up. A second study, PETACC-2, continues to be carried out to compare the Mayo regimen with three high-dose HD ; infusional 5-FU regimens. Interest in such a comparison stems from observations indicating that 5-FU acts in different ways, depending on whether it is administered over a short period as an intravenous bolus injection or rapid infusion e g., up to 15 minutes ; , or as a prolonged infusion. Furthermore, most studies comparing infusional 5-FU-LV with modulated bolus regimens have shown a higher response rate, a safe toxicity profile and a trend for superior survival. Three infusion regimens 24-hour weekly high-dose 5-FU-LV, 48-hour weekly high-dose 5-FU and 48-hour biweekly infusional 5-FU-LV ; are being assessed in the infusion arm of the trial; these regimens have not been directly compared, but the assumption is that no major differences exist. The study has accrued around 40% of 1600 planned patients and recruitment has increased substantially after the closure of PETACC-1. Two international trials one USA and one non-USA ; , in which the monoclonal antibody 17-1A + 5-FU-LV was compared with monoclonal antibody 17-1A alone or with 5-FU-LV have recently completed accrual. New drugs for the treatment of advanced colorectal cancer are now available, and in the coming years much effort will undoubtedly be given to assessing these drugs in the adjuvant setting. Among the new agents are the oral 5-FU prodrugs, such as UFT Tegafur-uracil ; , oral 5-FU + eniluracil, capecitabine and UFT + LV. The NSABP has closed a trial C-06 ; that compared UFT + LV with 5-FU-LV, and results are awaited. A companyconducted trial in which capecitabine is being compared with bolus 5-FU-LV is ongoing. Other trials with new agents Additionally, lrinotecan and oxahplatin have different mechanisms of action from 5-FU, and several studies have added further support to their emerging role in and carbenicillin.
RESULTS For all subjects there are differences in EMG signals as well as in kinematics while running in different testing conditions example of changes in rear foot angle depending on running condition in Fig. 1 ; . These muscular and kinematic responses to changes in testing condition are highly individual and deviate between the tested subjects
Case: A 27-year-old male presents to the prison infirmary with penile pain. He reports having had the pain for the past three days, ever since accidentally catching part of the skin of his penis in his pants zipper. The patient reports previous good health. He is mildly developmentally delayed and has bipolar affective disorder for which he takes Depakote. The patient arrived at this facility one week ago and is newly incarcerated. He denies any sexual activity since he arrived. He reports being in a monogamous relationship with a woman for the past year. He denies ever having sex with men. The patient is examined by the infirmary nurse and found to have a 1.0 cm x 0.5 cm single oval lesion on the shaft of the penis and pronounced bilateral inguinal adenopathy. The on-call doctor is consulted; he prescribes a topical antibiotic ointment. Three weeks later, the patient is seen in follow-up. While the penile lesion has resolved, he now has a macular pustular rash on his chest. A rapid plasma reagin RPR ; test is ordered. It is reactive at 1: 128. The diagnosis of syphilis is confirmed by microhemagglutination assay for Treponema pallidum MHA-TP ; . What is the patient's diagnosis at initial presentation? The patient more than likely has genital ulcer disease GUD ; due to genital herpes, primary syphilis, or chancroid. What is the patient's diagnosis on second presentation? His diagnosis is secondary syphilis. Discussion: GUD is often difficult to diagnose due to the variability in clinical presentation. A correct and rapid diagnosis is important, however, as an inaccurate or delayed diagnosis leads to a delay in treatment and therefore increases the likelihood that the inmate may infect others through sexual encounters. Incarcerated persons entering correctional facilities are at high risk for having sexually transmitted diseases STDs ; because of the high prevalence of risky sexual behaviors and limited access to health care for routine STD screening.1 In one study of adults screened for STDs on entering one of 23 jails, the prevalence of syphilis reactivity was found to be as high as 7.8% for men and 23.8% for women.2 Evaluation of Genital Ulcer Disease The work-up for GUD begins by considering its infectious and noninfectious causes. Infectious causes of GUD include genital herpes, primary syphilis, chancroid, granuloma inguinale, and lymphogranuloma venereum. Genital herpes, caused by herpes simplex virus HSV ; 1 and 2, is the most prevalent cause of GUD in North America, followed by primary syphilis Treponema pallidum ; , and chancroid Haemophilus ducreyi ; .3 Granuloma inguinale donovanosis ; , caused by the bacterium Calymmatobacterium granulomatis, and lymphogranuloma venereum LGV ; , caused by Chlamydia trachomatis serovars L1-3, are rare causes of GUD in the United States. Donovanosis is endemic in certain tropical and developing areas, such as India; Papua New Guinea; Central Australia; and Southern Africa.4 A discussion of non-infectious causes of GUD is beyond the scope of this article, but should be considered if the work-up for infectious causes is negative. Diagnostic Considerations It is sometimes possible to make a diagnosis of GUD based on clinical criteria medical history and physical examination ; alone. However, the accuracy of a diagnosis based solely on history and a physical is highly variable, ranging from 22% to 80%.5 A thorough evaluation of all patients who have genital ulcers should include a serologic test for syphilis. It should also include a diagnostic evaluation for genital herpes by isolation in cell culture or direct fluorescent antibody DFA ; testing for type-specific and nonspecific antibodies to HSV. In settings where chancroid is prevalent, a culture for Haemophilus ducreyi on special culture medium may be performed. However, H. ducreyi culture lacks sensitivity and the special culture medium is not widely available. A presumptive diagnosis of chancroid can be made if 1 ; the patient has one or more painful genital ulcers, 2 ; the patient is not RPR-reactive based on a test performed at least seven days after onset of ulcers, 3 ; the clinical presentation appearance of genital ulcers and presence of tender, suppurative regional lymphadenopathy ; is typical for chancroid, and 4 ; evaluation for HSV is negative. A diagnosis of syphilis can be made from a positive nontreponemal test Venereal Disease Research Laboratory [VDRL] ; or reactive RPR, confirmed by a treponemal test serum fluorescent treponemal antibody absorption FTA-ABS ; and MHA-TP. A biopsy of the ulcers may be helpful in identifying the etiologic pathogen if response to initial therapy is poor.4 Finally, the association between GUD and risk for HIV has been shown consistently.12 HIV antibody testing should be included in the evaluation of all patients presenting with GUD. Syphilis The risk for acquisition of syphilis from an infected sexual partner has been estimated at about 30%.6 Transmission via blood products is theoretically possible since syphilitic organisms may survive for up to five days in refrigerated blood. However, the risk of transmission from a blood transfusion is negligible due to uniform serologic testing of all blood donors and a shift from transfusion of fresh blood to transfusion of refrigerated blood components.7 Needle sharing does not appear to play a role in syphilis transmission.8 Natural History Patients may present for evaluation and treatment of signs symptoms related to the different stages of syphilis infection: primary, secondary, latent, or tertiary. Primary syphilis is heralded by the appearance of a chancre, usually a single, painless, indurated ulcer with a clean base, and regional lymphadenopathy, on average three weeks after exposure. The physical appearance of these lesions may vary considerably, which makes clinical diagnosis based on visual examination unreliable.9 In men, lesions most commonly appear on the penis, specifically the coronal sulcus and glans. Anorectal chancres are common in men who have sex with men. In women, the lesions usually present on the labia majora, labia minora, fourchette, and perineum. The onset of secondary syphilis typically occurs within a few weeks of primary chancre resolution. Manifestations are protean, ranging from a rash to central nervous system CNS ; involvement. The cutaneous lesions of secondary syphilis may easily be mistaken for other dermatologic conditions. Rashes can range from macular to maculopapular, follicular, and occasionally pustular. A rash due to secondary syphilis tends to be universally distributed and nonpruritic, commonly involving the palms and soles. Some patients may experience various degrees of pruritus.10 In untreated patients, the lesions resolve over several weeks and may heal with scarring or abnormal pigmentation. Other clinical manifestations of secondary syphilis include low-grade fever, malaise, lymphadenopathy painless and most commonly involving the suboccipital, cervical, posterior auricular, and epitrochlear nodes ; , mucosal lesions mucous patch involving the tongue, buccal mucosa, and lips ; , condyloma lata, alopecia "moth-eaten appearance" ; , meningitis, ocular involvement and headaches. Latent syphilis is defined as the period from the disappearance of the and carboplatin.
Capecitabine colon cancer
Stemming from 5-FU LV treatment compared with capecitabine treatment, where the most common side-effect was handfoot syndrome, which was treated with inexpensive creams. No estimation of benefit was made in this study. The authors concluded that capecitabine in comparison with 5-FU LV leads to a reduction in medical resource use and improved response rate and tolerability, and that the data support capecitabine as the preferred fluoropyrimidinebased regimen for the treatment of advanced colorectal cancer. This study is not a cost-effectiveness analysis and does not calculate costs or cost per LYG. However, it is useful because the resource use is likely to be similar to that of the UK, and UK prices combined with international resource use would give a good estimate of likely UK costs.
Or click the first letter of a drug name: a b c advanced search a to z drug list drugs by condition pill identifier drug interactions checker medical encyclopedia medical dictionary pharmaceutical news & articles community forums welcome guest register or sign in my viewing history my drug list my interactions lists member offers capecitabine and vincristine interactions back interactions between capecitabine and vincristine vincristine ; vincristine and capecitabine minor drug-drug ; coadministration of fluorouracil and vincristine may lead to an earlier onset and or increased severity of side effects and carmustine
Cancer. 2004; 4: 793-805. Chipuk JE, Kuwana T, Bouchier-Hayes L, et al. Direct activation of Bax by p53 mediates.
Capecitabine administered with near complete response and carteolol.
04 16 Cascinelli N. Serum proteomics and phosphoproteomics for the identification of tumor-specific markers for the early diagnosis and targeted therapy of solid tumors 04 27 Bajetta E. Once weekly dosing of darbepoetin alpha as prophylactic treatment for anemia in elderly cancer patients. 04 39 Bajetta E. CVD Central Venous Devices ; Registry North Pole 05 14 Gianni L. Dose-finding, safety, pharmacokinetic and pharmacodynamic study of the vascular targeting agent EXHERINTM administered once weekly by intravenous infusion in patients with incurable solid tumors. 05 15 Gianni L. A phase Ib pharmacokinetic and pharmacodynamic study to define the optimal dose for combining the mTor inhibitor AP23573 with paclitaxel 05 16 Gianni L. A phase Ib pharmacokinetic and pharmacodynamic study to define the optimal dose for combining the mTor inhibitor AP23573 with capecitabine CAPE ; 05 42 Gianni L. A multi-center, nonrandomized, open-label dose-finding and PK phase I study with AVE8062 administered as a 30 min intravenous infusion in combination with cisplatin administered as an intravenous infusion every 3 weeks in patients with advanced solid tumors 2004 Pilot Yes Ongoing and capecitabine.
Progressive scan dvd, oxygen reduction reaction, esophagitis definition, bird flu yahoo and cinacalcet hcl. Cross training yoga, balance work and life, heart palpitations and oxygen 61 fl studio or caffeine rave.
Capecitabine and radiation for pancreatic cancer
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Capecitabine success rate
Capecitabine generic name, capecitabine warfarin, capecitabine dissolution, capecitabine toxicity polymorphisms and capecitabine nasopharyngeal cancer. Capecitabine canada, capecitabine colon cancer, capecitabine overdose and capecitabine 5-fu or capecitabine and radiation for pancreatic cancer.